Plain-language summaries of the peptide and compound literature: mechanisms, trial data, comparisons and lab practice, with sources cited.
203 articles · 21 compound hubs · 9 subject areas
Sexual Health & Tanning
The melanocortin system comprises five G-protein coupled receptors (MC1R–MC5R) activated by endogenous peptides derived from POMC. Research overview of each receptor's biology, endogenous ligands, and pharmacological tools.
7 min read
Sexual Health & Tanning
Sildenafil (Viagra) was the first PDE5 inhibitor approved for erectile dysfunction. Research overview of its mechanism, PDE selectivity profile, pharmacokinetics, and comparison with tadalafil for research model selection.
6 min read
Sexual Health & Tanning
Tadalafil (Cialis) is a selective PDE5 inhibitor with a uniquely long half-life (~17.5h). Research overview of its cGMP/NO/PDE5 mechanism, pharmacokinetics, and applications in erectile dysfunction, pulmonary hypertension, and BPH research models.
6 min read
Peptides & Recovery
Melanotan II (MT-II) is a cyclic melanocortin peptide that activates MC1R in melanocytes to stimulate melanogenesis and skin pigmentation. Research overview of its mechanism, pharmacokinetics, and comparison with afamelanotide.
6 min read
Peptides & Recovery
PT-141 (bremelanotide) is a cyclic melanocortin peptide that activates MC3R and MC4R in the central nervous system to modulate sexual arousal. Research overview of its mechanism, pharmacokinetics, and applications in sexual dysfunction models.
6 min read
Weight Loss & GLP-1
Complete guide to retatrutide research dosing protocols — Phase 2 escalation schedules, reconstitution calculations for vials, and pen format instructions. Based on published clinical trial data.
7 min read
PCT & Support
Anastrozole (Arimidex) and letrozole (Femara) are both third-generation non-steroidal aromatase inhibitors, but differ in potency, pharmacokinetics, and optimal research applications. Research comparison guide for selecting the right AI.
6 min read
Peptides & Recovery
Post-cycle therapy (PCT) protocols use hCG, SERMs (tamoxifen, clomiphene), and aromatase inhibitors in sequence to restore hypothalamic-pituitary-testicular axis function after androgen suppression. Research guide to designing evidence-based PCT protocols.
7 min read
PCT & Support
Human chorionic gonadotropin (hCG) structurally mimics LH to directly stimulate Leydig cell testosterone synthesis. Research overview of its LHCGR signaling, ITT maintenance, and use in androgen suppression models.
6 min read
PCT & Support
Cabergoline (Dostinex) is a long-acting D2 dopamine receptor agonist used clinically for hyperprolactinemia and Parkinson's disease. Research overview of its prolactin suppression mechanism and use alongside 19-nor anabolic steroids.
5 min read
PCT & Support
Clomiphene citrate (Clomid) is a mixed SERM containing enclomiphene (ER antagonist) and zuclomiphene (ER agonist). Research overview of its HPTA stimulation mechanism, isomer pharmacology, and use in hypogonadism and fertility research.
6 min read
Peptides & Recovery
Tamoxifen is a selective estrogen receptor modulator (SERM) with tissue-specific ER antagonism (breast) and agonism (uterus, bone). Research overview of its mechanism, ERα/ERβ pharmacology, and applications in HPTA recovery and breast cancer research.
6 min read
PCT & Support
Letrozole (Femara) is the most potent non-steroidal aromatase inhibitor available, achieving near-complete estradiol suppression. Research overview of its mechanism, pharmacokinetics, and use in androgen/estrogen research protocols.
5 min read
PCT & Support
Anastrozole (Arimidex) is a third-generation non-steroidal aromatase inhibitor (AI) that suppresses estradiol synthesis by competitively inhibiting CYP19A1. Research overview of its mechanism, PK, and use in androgen/estrogen research protocols.
5 min read
Weight Loss & GLP-1
Head-to-head comparison of retatrutide (triple GIP/GLP-1/glucagon agonist) vs tirzepatide (dual GIP/GLP-1). Phase 2 and Phase 3 data, mechanism differences, and what the research says about each.
9 min read
Anabolic Research
Designing a multi-compound anabolic steroid research protocol requires understanding pharmacological complementarity, endpoint selection, and statistical framework. Research guide for designing testosterone + trenbolone + nandrolone/boldenone combination protocols.
8 min read
Anabolic Research
Methandrostenolone (Dianabol, D-bol) is a C17α-methylated Δ1,2-testosterone derivative with significant aromatization. Research overview of its pharmacology, historical clinical applications, and use in muscle protein synthesis research.
6 min read
Anabolic Research
Trenbolone and certain other androgens interact with the glucocorticoid receptor (GR) as partial agonists or antagonists. Research overview of GR-androgen interactions, anti-catabolic mechanisms, and research protocols for studying GR cross-reactivity.
7 min read
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