Mitochondrial, neuroprotective and anti-ageing research: NAD+, MOTS-c, SS-31, Semax, Selank.
8 articles
Longevity & Cognitive
Mitochondrial biogenesis is the process of forming new mitochondria — regulated by PGC-1α and upstream activators including AMPK, SIRT1, and NAD+. Research guide to the biogenesis pathway, compounds that activate it, and experimental models for measuring mitochondrial function.
5 min read
Longevity & Cognitive
MOTS-c is a mitochondrial 12S rRNA-encoded peptide that acts as a metabolic hormone — regulating glucose metabolism, insulin sensitivity, AMPK activation, and exercise adaptation. Research overview.
9 min read
Longevity & Cognitive
SS-31 (Elamipretide, MTP-131) is a mitochondria-targeted peptide that protects cardiolipin, restores cristae architecture, and prevents age-related mitochondrial dysfunction. Research overview and protocols.
9 min read
Longevity & Cognitive
Current state of longevity research covering the most studied interventions — rapamycin, senolytics (dasatinib + quercetin), NAD+ precursors, GH axis peptides, and where the field is heading.
9 min read
Longevity & Cognitive
Comparison of direct NAD+ administration versus NMN and NR precursors — bioavailability, tissue NAD+ elevation, mechanism differences, and which form is appropriate for different research applications.
8 min read
Longevity & Cognitive
Semax is an ACTH4-10 analog with neuroprotective and nootropic properties. This article covers Semax's structure, BDNF/NGF upregulation, anti-stroke research, cognitive effects, and research protocols.
9 min read
Longevity & Cognitive
Deep dive into NAD+-dependent sirtuins — SIRT1 through SIRT7, their substrates, deacetylase mechanism, mitochondrial vs. nuclear roles, and why elevating NAD+ activates longevity programs.
9 min read
Longevity & Cognitive
NAD+ (nicotinamide adenine dinucleotide) declines with age and is required for energy metabolism, DNA repair, and sirtuin activation. This article reviews NAD+ biology, aging decline mechanisms, and longevity research.
8 min read
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