Melanocortin research: PT-141, melanotan and related pathways.
4 articles
Sexual Health & Tanning
PT-141 (bremelanotide) acts centrally via MC4R to enhance sexual arousal and motivation, while PDE5 inhibitors (sildenafil, tadalafil) act peripherally on vascular smooth muscle. Mechanistic comparison for selecting the appropriate research compound.
6 min read
Sexual Health & Tanning
The melanocortin system comprises five G-protein coupled receptors (MC1R–MC5R) activated by endogenous peptides derived from POMC. Research overview of each receptor's biology, endogenous ligands, and pharmacological tools.
7 min read
Sexual Health & Tanning
Sildenafil (Viagra) was the first PDE5 inhibitor approved for erectile dysfunction. Research overview of its mechanism, PDE selectivity profile, pharmacokinetics, and comparison with tadalafil for research model selection.
6 min read
Sexual Health & Tanning
Tadalafil (Cialis) is a selective PDE5 inhibitor with a uniquely long half-life (~17.5h). Research overview of its cGMP/NO/PDE5 mechanism, pharmacokinetics, and applications in erectile dysfunction, pulmonary hypertension, and BPH research models.
6 min read
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