Plain-language summaries of the peptide and compound literature: mechanisms, trial data, comparisons and lab practice, with sources cited.
203 articles · 21 compound hubs · 9 subject areas
Peptides & Recovery
Semaglutide is a GLP-1 receptor agonist developed by Novo Nordisk and widely researched for weight loss and glycemic control. This overview covers its structure, mechanism, pharmacokinetics, and research applications.
8 min read
Longevity & Cognitive
MOTS-c is a mitochondrial 12S rRNA-encoded peptide that acts as a metabolic hormone — regulating glucose metabolism, insulin sensitivity, AMPK activation, and exercise adaptation. Research overview.
9 min read
Longevity & Cognitive
SS-31 (Elamipretide, MTP-131) is a mitochondria-targeted peptide that protects cardiolipin, restores cristae architecture, and prevents age-related mitochondrial dysfunction. Research overview and protocols.
9 min read
Longevity & Cognitive
Current state of longevity research covering the most studied interventions — rapamycin, senolytics (dasatinib + quercetin), NAD+ precursors, GH axis peptides, and where the field is heading.
9 min read
Peptides & Recovery
A mechanistically rational anti-aging research stack combining BPC-157, TB-500, Ipamorelin + CJC-1295, and NAD+/NMN — covering tissue repair, GH axis, and cellular longevity pathways in one protocol design.
8 min read
Longevity & Cognitive
Comparison of direct NAD+ administration versus NMN and NR precursors — bioavailability, tissue NAD+ elevation, mechanism differences, and which form is appropriate for different research applications.
8 min read
Longevity & Cognitive
Semax is an ACTH4-10 analog with neuroprotective and nootropic properties. This article covers Semax's structure, BDNF/NGF upregulation, anti-stroke research, cognitive effects, and research protocols.
9 min read
Longevity & Cognitive
Deep dive into NAD+-dependent sirtuins — SIRT1 through SIRT7, their substrates, deacetylase mechanism, mitochondrial vs. nuclear roles, and why elevating NAD+ activates longevity programs.
9 min read
Longevity & Cognitive
NAD+ (nicotinamide adenine dinucleotide) declines with age and is required for energy metabolism, DNA repair, and sirtuin activation. This article reviews NAD+ biology, aging decline mechanisms, and longevity research.
8 min read
Growth Hormone
Comprehensive review of growth hormone's effects on body composition — mechanisms of GH-driven lipolysis and muscle anabolism, published body composition data, and how GH secretagogues compare to rhGH in lean/fat ratio studies.
9 min read
Growth Hormone
Comparison of HGH pen injectors and traditional vial+syringe systems for growth hormone research — delivery precision, storage, reconstitution requirements, and practical considerations.
7 min read
Growth Hormone
Reference guide for rhGH (somatropin) dosing in rodent and larger animal research models — conversion from IU to mg, dose-response data, pulsatile vs. continuous administration, and endpoint selection.
8 min read
Growth Hormone
Growth hormone declines with age (somatopause). This article reviews the GH–IGF-1 axis changes in aging, longevity paradoxes in lower-IGF-1 models, GH secretagogue research in age-related decline, and current evidence.
9 min read
Growth Hormone
The relationship between growth hormone and IGF-1 — somatogenic liver signaling, STAT5 pathway, IGFBP regulation, feedback loops, and why IGF-1 is the primary mediator of GH's anabolic effects.
8 min read
Growth Hormone
PEG-MGF (Pegylated Mechano Growth Factor) stimulates satellite cell activation for muscle repair — mechanism, IGF-1Ec splice variant biology, PEGylation half-life extension, and research protocols.
10 min read
Growth Hormone
HGH Fragment 176-191 is the C-terminal region of GH responsible for fat mobilization. This article covers its lipolytic mechanism, GHR independence, adipocyte signaling, and research protocols.
9 min read
Growth Hormone
Complete overview of recombinant human growth hormone — structure, mechanism, receptor biology, IGF-1 axis, and how rhGH differs from endogenous GH and GH secretagogues in research applications.
9 min read
Growth Hormone
A mechanistic overview of the GH secretagogue class — GHS-R1a pharmacology, the ghrelin axis, pituitary somatotroph biology, and how synthetic GHRPs and GHRH analogs activate the GH axis.
9 min read
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